Endocrine Abstracts

A lot of new data have been recently generated regarding the complex relationship between the thyroid function and metabolic parameters.The aim of the study was to estimate the obesity and metabolic syndrome (MS) rates according to the age and the thyroid function in the residents of Belarus.We have examined 894 subjects aged 18–44 years (82.2% females) living in Stolin district, Brest region of Belarus. The endocrinological e...

Aim: To show the etiology of thyromegaly in our region to asses the rationale treatment and follow up.Material and methods: Between 2005 and 2010, we have studied the prevalence and etiologic profile of the children with thyromegaly admitted in the Endocrinology Department of our hospital. The working protocol included: weight and length birth, gestational age, auxological parameters and pubertal stages after Tanner’s criteria, morphogram, laborator...

Aim: To estimate QOL and intensity of depression symptoms in T1DM patients.Materials and methods: Total 53 T1DM patients (26m, 27f), mean age (M±σ) 33.6±2.7 years (20.00–54.00) and 35 of the control group (17m, 18f), mean age 34.8±2.9 years (22.00–50.00) were provided with the questionnaire of Medical Outcomes Study 36-Item Short-Form Health-Survey, Beck depression inventory and Test for estimation of subjective contr...

Tumoral calcinosis is a rare autosomal recessive disease characterized by hyperphosphatemia due to increased renal phosphate reabsorption leading to soft tissue calcifications. The levels of fibroblast growth factor 23 (FGF23), a hormone required for normal renal phosphate reabsorption, are typically low in the classic form of the disease due to homozygous missense mutations in FGF23 or in the UDP-Nacetyl-alpha-D galactosamine:polypeptide N-acetylgalactos...

Objectives: Besides well known increased adrenal androgen production, an enhanced peripheral cortisol metabolism was also observed in polycystic ovary syndrome (PCOS). This could induce a compensatory rise of ACTH secretion, tending to maintain normal plasma cortisol concentration at the expense of adrenal androgen excess. On the other hand, obesity is associated with a hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis and impaired androgen balance. In t...

Objectives: It is well known that polycystic ovary syndrome (PCOS) can promote metabolic syndrome (MetSy) and consequently cardiovascular diseases (CVD). In this study we compared indices of MetSy and 10-year cardiovascular risk (CVR10) based on Framingham risk scoring system (FRSS) in young obese PCOS women and healthy obese controls.Methods: We studied 25 obese women with PCOS (mean age: 29.55±4.6 years, mean BMI: 31.8±4.4 kg/m<sup...

Aim: To evaluate the frequency and morpho-histological characteristics of the colonic polyps (CP) in acromegaly patients (pts).Materials and methods: We studied 53 pts (50 female, 3 men) aged 23–76 (median – 47) with active acromegaly. The mean disease duration was 10.7±4.3 years. Somatotropinoma was diagnosed in 51 pts and somatoprolactinoma in two. The activity of acromegal? was confirmed on the base of the clinical and hormonal data. Ba...

Chordomas are slow growing neoplasms arising from notochordal remnants of the axial skeleton. The second most common site for chordomas, after the sacrococcygeal region, is the base of the skull. We describe one case of sellar and suprasellar chordoma found in a 44 year old female, with tumoral syndrome, bitemporal hemianopsia and secondary amenorrhea. Skull X-ray showed an enlarged sella turcica with destruction of the dorsum and impressive intra- and suprasellar calcificatio...

AimDepression in diabetic patients is related to low quality of life, inadequate abiding by diabetes diet, physical activity and drug therapy.Aim of the stady is determine the presence of depression and its impact on the level of metabolic control of the disease; impact of structured education on the level of knowledge and HbA1c in patient with diabetes type 1 (T1D)MethodsThe study included 38 patients with T...

Graves’ disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Thyroid dermatopathy (TD) is a rare extrathyroidal manifestation of GD, almost always associated with Graves’ orbitopathy ...